The first thing I do when I fire up the bike is to put it in Economy mode. When I want to get spirited and hammer the throttle open, it doesn't affect anything anyway.
It's completely disengaged when you're above 6,000 rpm, or the throttle is over 30% open, or your speed is over 80 mph (per the speedo, not actual). So, highway cruising at 75, I get pretty good mileage. Backroads or in the Hill Country, not so much. Unless I'm in that "spirited" mode, I'm close to 200 miles per tank on my '11. I'm sure I could squeeze a little more out of it if I knew that I really had a long way between gas stations.
In my mind, there's no reason NOT to run in it Economy mode all the time. I just wish the bike "remembered" the last setting on startup.