Doesn't the pick-up always suck gas from the bottom of the tank anyway? Seems like if there's crap in the bottom of the tank, the amount of fuel sitting on top of it isn't going to affect whether or not it gets sucked into the filter/pump.
the C14 fuel pump pulls fuel from 2 areas, one just off the bottom of the tank, another about 2 " up. Both areas pull fuel thru a "filter pad" of sorts, and also thru a "sock" of mesh.
The high probability of having some moisture in a tank is always there, but the water "globules' tend to slosh around and keep moving because they are a different (thicker) vicosity, the look like "bubbles' when you see them, and thay tend to keep moving. Totally sucking the tank dry insures that you WILL suck them up, this is not good as they will clog the fliter, and carry anything like debris and particulate matter (dust) along with them.
Rebuilding the fuel pump, cleaning the pads, and such Is possible, but it's very tricky, and you take chances with damaging components internally. It is not shown as a servicable item, it is a "replace" thing, and it costs big bucks.....best to do what I say, and never let the fuel get that low. I also suggest sucking the bottom of the tank out periodically using a mightyvac to remove any debris and moisture.....pre-emptively.
Our departed Aussi friend Davo (RIP) did a very comprehensive article on rebuilding this, he had lots of problems with the fuel in his area as far as contaminants go. If aanyone has a link, it would make a good stickey.