I have trouble with my hands and wrists too. I've got risers, wedges, grip puppies, BMW grips, so far nothing has completely resolved the issue. My current working theory is that the grip angle is too far toward the rear. In other words, my natural hand position, when I just let them fall onto the grip, is straighter than the grip, forcing me to rotate my wrist outward on both sides to line up. The result is that I end up with my carpal nerve bearing weight and the "heel" of my hand getting tired and sore. I've already had the C-T surgery years ago, so that's not an option now.
I decided to experiment, and I can't tell you yet how it's going to work out. I picked up a spare set of bars on eBay, and they are at the machine shop right now getting modified. When I get them back, there will be an 8 degree angle forward where they come out of the upright. My wooden mock-ups indicate that 8 degrees is the amount of change I would need to have my hand fall naturally on the grip in the correct position for me.
They are going to cut the bars off, between the upright and the brake/clutch lever, at a 4 degree angle. Then rotate one part of the bar 180 degrees, and weld it back up. They're going to cut a pretty deep bevel into the weld and run 2 or three beads around for maximum strength, but they warned me that it still might not be as strong as before. Definitely strong enough to steer the bike, but possibly not strong enough if the bike fell and had to be lifted up by the handlebar alone. We are already in discussions about reproducing the entire bar, with the 8 degree bend, in steel. That's going to cost more so I'm waiting to see if the angle "correction" pleases me.
While I understand that steel would weigh roughly 3 times as much as the stock bars, one possible advantage is that they would act like the biggest set of bar-end weights ever produced. Might cut vibration down even more!
Since I got the seat perfected, the bars are the only issue left I haven't been able to resolve. Should have them back on Thursday, then we'll see.